Pure Essence
With people crafting Nature Runes, this will surely be at least twice as profitable as mining Rune Essence right now. I predict at least 60-70gp per ess
Nature Running
Requires Shilo Village completed. Get an inventory of essence and a Nature Talisman, and trade people doing 2x nats ess for nats
Picking Flax
Flax picking in 2004 was extremely tedious - And there’s no bots to do it this time! Flax is definitely going to be more expensive than Pure Essence, so maybe 80-90gp per
Spinning Flax
Spinning is also tedious in 2004, but maybe not as bad as flax. I suspect 60-70gp profit per spun bowstring.
Chaos Druids
You know these boys will be packed! You can find them in Edge dungeon and Tavlery dungeon, but some lesser known spots include the Yanille dungeon and the Chaos Druid Tower that is North West of Ardougne
Green Dragons
Watch out for PKers! Crafters will be making Green D’hide bodies, which alch for 4k each. That means each dragonhide will be worth at least 1k (not to mention the Dragon Bones!)
Black Dragons
I’ve heard predictions that Black Dragonhide sets will go for up to 500k each. There’s only 3 places to get the d’hide; two are in the wildy, and the third is in Tavlery dungeon. The competition will be fierce, but the hides will be expensive!